Research Articles
The Biosynthetic Logic of Polyketide Synthases: From Assembly Line Mechanisms to Drug Discovery and Engineering
This article provides a comprehensive analysis of the biosynthetic logic underpinning polyketide synthases (PKSs), tailored for researchers, scientists, and drug development professionals.
Biological vs. Chemical Synthesis: A Comparative Analysis for Modern Drug Development
This article provides a comprehensive comparative analysis of biological and chemical synthesis, two pivotal methodologies in pharmaceutical development.
Foundation Models for Materials Discovery and Synthesis: A New Paradigm for AI-Driven Scientific Innovation
Foundation models, large-scale AI systems pre-trained on vast datasets, are revolutionizing materials science and drug development.
Harnessing RiPP Biosynthetic Pathways for Next-Generation Peptide Engineering and Drug Discovery
This article provides a comprehensive analysis of Ribosomally synthesized and post-translationally modified peptides (RiPPs) as versatile platforms for peptide engineering.
Biocompatible Chemistry for Plastic Waste Upcycling: Bridging Synthetic and Biological Systems for a Sustainable Future
This article explores the emerging frontier of biocompatible chemistry for plastic waste upcycling, a field that strategically merges synthetic and biological catalysis.
Computational Tools for Biosynthetic Pathway Prediction: A Guide for Drug Development and Synthetic Biology
This article provides a comprehensive overview of the computational tools and methodologies revolutionizing the design and optimization of biosynthetic pathways for drug development.
Retrosynthetic Analysis in Biology: Computational Design of Biosynthetic Pathways for Drug Development
This article explores computational retrosynthetic analysis for designing biosynthetic pathways to produce valuable natural products and therapeutics.
Engineering Enzyme Thermostability: AI-Driven Strategies for Robust Industrial and Biomedical Applications
This article provides a comprehensive overview of modern strategies for engineering enzyme thermal stability, a critical property for industrial and pharmaceutical biocatalysis.
Engineering Biosynthesis: Synthetic Biology Approaches for Sustainable Magnolol Production
This article comprehensively reviews the application of synthetic biology to address critical challenges in magnolol production.
In Vitro Reconstitution of Biosynthetic Pathways: A Foundational Guide from Discovery to Clinical Translation
This article provides a comprehensive overview of the in vitro reconstitution of biosynthetic pathways, a powerful methodology that excises enzymatic pathways from their native cellular environments for detailed study and...